Solution : https://service.sap.com/sap/support/notes/135048 (SAP Service marketplace login required)
Key words : 
symptom long response times occur, delete parameter dbs/ora/use_hints, oracle shared cursor caches, dbs/ora/use_hints = upto->1000, dbs/ora/use_hints =, special parameter setting, sort merge join, full table scan, lowest resource consumption, solution sap offers
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