SAP Message SB300 - Error in remote connection to SAP System &1 (destination &2): &3&4

Diagnosis
An error occurred during RFC communication with the SAP system &V1&.V2 was used as a destination (maintain destinations in transactionSM59). The message returned by the RFC interface is:
V3v4

System Response
No data was transmitted from or to the remote system.

Procedure
Notify the system adminstration.